en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div dir="ltr" style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:12px;"><strong>Background. </strong>Exercise has significant affects on free radical production.<br> <strong>Objective. </strong>The objective of the present study was to explore the effect of vitamin C supplementation on lipid peroxidation and lactate levels in sedentary individuals who performed exhaustion exercised.<br> <strong>Methods. </strong>10 healthy sedentary male athletes participated to study. They were supplemented with 300 mg oral vitamin C (L-ascorbic acid, Ester-C Plus 500 mg, Solgar-USA) and subjected to acute exhaustion exercise by fatigue developed one time a week for 4 weeks. Exhaustion exercises were carried out until exhaustion developed according to Bruce protocol once a week for 4 weeks. Blood samples were collected from the subjects four times, at the beginning and at the end of the supplementation and before and after exercise, over the 4-weeks study period. The samples were used to analyze MDA, GSH, GSH-Px, CAT, SOD and NO levels by using ELISA colorimetric method and plasma lactate levels by an autoanalyzer device.<br> <strong>Results. </strong>Exhaustion MDA, GSH, GSH-Px, CAT, SOD and NO levels measured both before and after supplementation were higher than resting levels (p<0.05). MDA, NO and lactate levels that were elevated in exhaustion before supplementation decreased significantly after vitamin C supplementation (p<0.05).<br> <strong>Conclusion. </strong>The results of our study indicate that the increase in free radical production and lactate levels due to by 4-week exhaustion exercise were offset by vitamin C supplementation. It can be argued in conclusion that supplementation of physiologic doses of vitamin C may be useful for athlete health and performance.</span></span></div> Vitamin C, Exercise, Free Radicals, Antioxidant Activity, Lactate 21 27 http://aassjournal.com/browse.php?a_code=A-11-585-1&slc_lang=en&sid=1 Süleyman Patlar s.patlar@yahoo.com.tr 10031947532846004207 10031947532846004207 Yes Faculty of Sport Sciences, Selcuk University, Konya,Turkey Abdulkerim Kasim Baltaci baltaci61@yahoo.com 10031947532846004208 10031947532846004208 No Department of Physiology, Medical School, Selcuk University, Konya, Turkey Rasim Mogulkoc rasimmogulkoc@yahoo.com 10031947532846004209 10031947532846004209 No Department of Physiology, Medical School, Selcuk University, Konya, Turkey Mehmet Gunay mgunay@selcuk.edu.tr 10031947532846004210 10031947532846004210 No School of Physical Education and Sports, Gazi University, Ankara, Turkey