en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div dir="ltr" style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:times new roman;"><strong>Background. </strong>The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain.<br> <strong>Objective(s). </strong>This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues..<br> <strong>Methods. </strong>Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 &plusmn;63.09 gr) were used. After being taken to the animals&rsquo; laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method.<br> <strong>Results.</strong> Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959).<br> <strong>Conclusion.</strong> It can be established that both resistance and endurance training can similarly affect the production and secretion of exercise-induced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.</span></span></div> FNDC5, Liver, Resistance Training, Endurance Training 51 60 http://aassjournal.com/browse.php?a_code=A-11-545-1&slc_lang=en&sid=1 Amir Rashidlamir rashidlamir@um.ac.ir 10031947532846004271 10031947532846004271 Yes Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran Mohammad Hoseinzadeh mhzadehsport@gmail.com 10031947532846004272 10031947532846004272 No Department of Physical Education, Farhangian University, Tehran, Iran Leili Zeiaddini Dashtkhaki lziaadini@yahoo.com 10031947532846004273 10031947532846004273 No Department of Physical Education, Kerman Branch, Islamic Azad University, Kerman, Iran