en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <p dir="ltr" style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:times new roman;">Inflammation and pain induced by delayed onset muscle soreness (DOMS) can be induced by eccentric exercise or an unaccustomed activity. The condition can causes problems in exercising and for athletes. The purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. Evaluations were made for total antioxidant Capacity (TAC), muscle damage markers, and DOMS induced pain. Ten healthy young males (age, 25.0 &plusmn; 1.6 years; height, 178.9 &plusmn; 4.1 cm; body mass, 81.1 &plusmn; 6.8 kg; fat%, 14.2 &plusmn; 2.1) completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg) and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin (CU) or placebo (P) was taken at the prescribed dose immediately after eccentric squat exercises; administrations were separated by a 14-day washout period. Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a) limb pain (1&ndash;10 cm visual analogue scale; VAS), (b) total antioxidant capacity (TAC) (c) serum markers of muscle damage and inflammation. Measurements taken after exercise showed significantly reduced levels of pain, creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in C group compared with group P group (P<0.05). TAC remained significantly high in group C after exercise compared with levels in group P (P<0.05). The findings of this study suggest that a 150mg dose of curcumin may have antioxidant, anti-inflammatory and analgesic effects on DOMS.</span></span></p> Delayed Onset Muscle Soreness (DOMS), Curcumin, Total Antioxidant Capacity (TAC), Muscle Damage, Squat Exercises 25 31 http://aassjournal.com/browse.php?a_code=A-11-533-1&slc_lang=en&sid=1 Babak Nakhostin-Roohi b.nakhostinroohi@iauardabil.ac.ir 10031947532846002896 10031947532846002896 Yes Department of Sport Sciences, Faculty of Humanities, Ardabil Branch, Islamic Azad University, Ardabil, Iran Arash Nasirvand Moradlou arashnasirvand1369@gmail.com 10031947532846002897 10031947532846002897 No Department of Physical Education, Mohaghegh Ardabili University, Ardabil, Iran Sahar Mahmoodi Hamidabad sahardaneshgah72@gmail.com 10031947532846002898 10031947532846002898 No Department of Physical Education, Mohaghegh Ardabili University, Ardabil, Iran Babak Ghanivand babak.ghanivand@gmail.com 10031947532846002899 10031947532846002899 No Department of Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran