en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background. </strong>Aging is a complex and multifaceted process leading to a widespread decline in nerve function. In addition to causing weakness in the elderly, neurological disorders in old age are also effective in the development of chronic diseases.<br> <strong>Objectives. </strong>Therefore, this study aims to investigate the effect of eight weeks of HIIT exercises on LRP1, AB1-42, and insulin resistance in obese elderly diabetic rats.<br> <strong>Methods. </strong>Twenty-four rats (20 months old) were bred, 16 diabetic rats were randomly divided into two diabetic control groups (SHAM) and diabetic exercise (HIIT), and the remaining eight rats were in the healthy control group (CON). After making sure that the rats became diabetic, they were familiarized with the treadmill for a week, and the maximum speed test was performed to calculate the training intensity for the training group. Then, the rats in the HIIT group ran five sessions every week for 8 weeks on a treadmill with a Vo2max intensity of 90% in 30-second intervals. The incline of the treadmill was zero in all training sessions. The training started in the first week with 5 30-second moves for each session, and one move was added every week so that it reached 12 moves by the eighth week. In all weeks, the rats rested for one minute between intervals (continuing the treadmill at 7.8 m/min, equivalent to 30% of the maximum speed).&nbsp;<br> <strong>Results. </strong>After eight weeks of HIIT exercises, a significant difference was observed between the AB1-42 index of the groups (P=0.001). The results of the follow-up test showed that there was a significant difference between AB1-42 of the exercise group with the diabetic control group, the healthy control group, and the diabetic control group with the healthy control group (P=0.001, P=0.001, and P=0.001, respectively). A significant difference was observed between LRP1 groups (P=0.001). The follow-up test results showed a significant difference between the LRP1 of the exercise group and the diabetic control group and the healthy control group and the diabetic control group (P=0.001 and P=0.001, respectively). Also, after eight weeks of training, there was a significant change in weight, glucose, insulin, and insulin resistance indices (P=0.001, P=0.001, and P=0.001, respectively).<br> <strong>Conclusion. </strong>It is suggested that by participating in HIIT exercises, the elderly can reduce the process of nerve tissue damage and the progress of diseases such as diabetes.</div> Diabetes, HIIT, High-Intensity Interval Training, LRP1, AB1-42, Obese Elderly, Diabetic Rats 0 0 http://aassjournal.com/browse.php?a_code=A-11-2401-1&slc_lang=en&sid=1 Marzieh Sadat Azarniveh m.azarnive@uoz.ac.ir 100319475328460015612 100319475328460015612 Yes Department of Sports Sciences, Faculty of Literature and Humanities, Zabol University, Zabol, Iran. Halimeh Vahdatpoor Vahdatpoor.114@gmail.com 100319475328460015613 100319475328460015613 No Phd of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran. Mitra Khademosharie m.khadem.un@gmail.com 100319475328460015614 100319475328460015614 No Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Bojnord, Iran. Frank Balaghi Inaloo Faranakbalaghi70@gmail.com 100319475328460015615 100319475328460015615 No Phd of Sports Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran. Asma Taheri a.taheri@ssu.ac.ir 100319475328460015616 100319475328460015616 No Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.