en فيزيولوژی ورزشی و شاخه‌های وابسته بدان Sport Physiology and its related branches مقاله اصیل Original Article <div style="text-align: justify;"><strong>Background. </strong>Optimisation of bone health from exercise interventions and nutritional supplements was recommended.<br> <strong>Objectives. </strong>This study aimed to determine whether L-carnitine supplementation combined with interval exercise training influenced bone metabolism markers and muscular strength and power in individuals with overweight and obesity.<br> <strong>Methods. </strong>This randomized controlled trial study involved sixty-eight participants in four groups, i.e., control (C, n=17), L-carnitine supplementation alone (Lc, n=17), exercise alone (Ex, n=17), and combined L-carnitine supplement and exercise (LcEx, n=17) groups. The participants in the Ex and LcEx groups participated in a 60-minute exercise program per day, 3 times a week, for 12 weeks at 50% heart rate reserved for brisk walking and 40-60% for interval exercise training. The participants in the Lc and LcEx groups consumed 1000 mg of L-carnitine supplement daily. The blood measurements for serum alkaline phosphatase (ALP), total calcium, and serum C-terminal telopeptide of type 1 procollagen (1CTP) were measured at weeks 0 and 12.<br> <strong>Results. </strong>The result showed that the LcEx group showed the most remarkable increment in ALP (p<0.05) and total calcium (p<0.05); however, it showed a reduction in serum 1CTP (p = 0.003). Regarding muscular performance, the LcEx group (p<0.05) also demonstrated a more significant increase in overall measured parameters of dominant knee extension and flexion peak torque and average power at 60o.s-1 and 300o.s-1 compared to other groups after 12 weeks.<br> <strong>Conclusion. </strong>Combining L-carnitine supplementation with brisk walking and interval training can enhance bone formation and muscle performance in people who are overweight and have obesity.</div> Exercise, Performance, Physical Activity, Obesity, Body Weight. 0 0 http://aassjournal.com/browse.php?a_code=A-11-2353-3&slc_lang=en&sid=1 Norsuriani Samsudin norsuriani.s@umk.edu.my 100319475328460016729 0009-0002-9698-7083 No Faculty of Hospitality, Tourism, and Wellness, Universiti Malaysia Kelantan City Kampus, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia Nur Syamsina Ahmad nursyamsina@usm.my 100319475328460016730 100319475328460016730 Yes Exercise and Sports Science Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia Foong Kiew Ooi fkooi@usm.my 100319475328460016731 100319475328460016731 No Exercise and Sports Science Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kelantan, Malaysia Azidah Abdul Kadir azidahkb@usm.my 100319475328460016732 100319475328460016732 No Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia Nur Karyatee Kassim karyatee@usm.my 100319475328460016733 100319475328460016733 No Basic Science and Oral Biology Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia